The Use of Lectin Gel in the Treatment of Thermal Burns in Rats Immunocompromised

Abstract

Thisstudy aimed at evaluating the use of lectin gel in the treatment ofsecond-degree burns in rats immunocompromised. Thirty-two male rats were randomly divided into two groups (G1 = treatment with hydrogel containing 100 μg / ml Cramoll 1,4 and G2 = Control, hydrogel without lectin). Thermal lesions were produced in the animals of both groups, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99° C ± 2° C/10 min in the dorsal proximal region for 15 sec. After 7, 14, 21 and 28 days, animals were euthanized. The percentage of tissue shrinkage in the group treated with lectin at 28 days was 81.0 ± 2.2 %. There was no sign of infection, bleeding or secretion. There were nosignificant differences inbiochemical and hematological parametersanalyzed.Histological evaluation of G1revealed: on the 7th day moderate inflammatory infiltrate and mild fibrosis, on the 14th day intense autolysis, neovascularization, mild fibroblast proliferation and intensefibrosis, on the 21st day re-epithelialization, non-modeled and densecollagen, moderate fibrosis and on the 28th day complete tissue epithelialization. These results extend the potential of therapeutic applications for Cramoll 1,4 in the treatment of thermal burns in immunocompromised animals.