Applicability of Homologous Fibrin Sealant in Bone Repair: An integrative Review

Abstract

The repairing of bone defects is still a challenge for researchers and clinicians. Nonetheless there are many procedures that use different biomaterials such as scaffolds for bone regeneration however the results are often still unsatisfactory. As a result, the fibrin sealant derived from the interaction between proteins participating in the final blood coagulation cascade, is one of the most promising biopolymers in the tissue engineering field due to its unique characteristics. The present study aimed to perform a systematic review on homologous fibrin sealants highlighting its applicability as a three-dimensional framework in the process of bone regeneration. The database used for search strategy was the PubMed (Medline) and followed the guidelines provided in the PRISMA statement. From an initial 313 articles, only 12 articles between 2009 to 2019 were selected for this review after checking all inclusion and exclusion criterias. Due to this background, it is notable that fibrin sealant is one of the promising biopolymers used for tissue engineering and bone regeneration applications.