Antifungal and Antiplasmodial Activity of Isolated Compounds from Handroanthus serratifolius (Vahl) S. Grose Sawdusts

Authors

  • Loretta Ennes Sabóia de Melo
  • Katia Santana Cruz
  • Pedro Igor Lima Soares
  • Claudete Catanhede do Nascimento
  • João Vicente Braga de Souza
  • Brenna Marceliane de Melo Marcelino
  • Valter Ferreira de Andrade-Neto
  • Antonio Gilberto Ferreira
  • Maria da Paz Lima

Abstract

Handroanthus serratifolius (Vahl) S. Grose [Tabebuia serratifolia (Vahl) G. Nicholson] popularly known in Brazil “ipê-amarelo" is a woody species with potential of sustainable use belonging to a genus known for being as a promising naphthoquinones source which has aroused interest in search for new biological activities. In this paper, the methanolic extract fractionation from H. serratifolius sawdust using different chromatogramphic techniques yielded naphthoquinones dehydro-α-lapachone, dehydro-iso-α-lapachone and α-lapachone, along with lignans paulownin and cycloolivil. The three naphthoquinones presented antiplasmodial activity against Plasmodium falciparum where the dehydro-iso-α-lapachone was more active (IC50 of 7.53 μg/mL). This same compound also exhibited significant antifungal activity against Cryptococcus neoformans.

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Published

2019-10-05

Issue

Vol. 6 No. 9 (2019): Sept 2019

Section

Articles

How to Cite

Melo, L. E. S. de, Cruz, K. S., Soares, P. I. L., Nascimento, C. C. do, Souza, J. V. B. de, Marcelino, B. M. de M., Andrade-Neto, V. F. de, Ferreira, A. G., & Lima, M. da P. (2019). Antifungal and Antiplasmodial Activity of Isolated Compounds from Handroanthus serratifolius (Vahl) S. Grose Sawdusts. International Journal of Advanced Engineering Research and Science, 6(9). https://journal-repository.com/index.php/ijaers/article/view/169