Antiulcer, analgesic and hepatoprotective activities of hydroalcoholic root extract of Jurinea Dolomiaea Boiss against carbon tetrachloride induced hepatopathy in rats

Abstract

The plant Jurinea Dolomiaea Boiss belonging to family Astraceae traditionally used in Ayurvedic system as antidiabetic, antioxidant, antibacterial, antitumor and also used in liver disorders. In this study, water and hydroalcoholic root extracts of Jurinea dolomiaea boiss was studied for antiulcer, analgesic and hepatoprotective properties against carbon tetrachloride induced hepatotoxicity in albino wistar rats. Hydroalcoholic extract of Jurinea dolomiaea root (100mg/kg and 200mg/kg p.o) were administered to the experimental rats for seven days. The hepatoprotective activity of hydroalcoholic extract of Jurinea dolomiaea roots were evaluated by estimation of SGOT, SGPT, ALP and total bilirubin. Histopathology of the liver was also studied. In the hydroalcoholic extract of Jurinea dolomiaea roots treated animals, the toxic effect of carbon tetrachloride was controlled significantly by restoration of the increased levels of SGOT, SGPT, ALP and total bilirubin as compare to the toxicant control. The hydroalcoholic extract of roots of Jurinea dolomiaea showed significant hepatoprotective activity.