Psoriasis flare-up phenomenon after covid-19 vaccine

Abstract

Psoriasis is an immune-mediated chronic inflammatory disease. There are several intrinsic and extrinsic factors that can initiate the disease in predisposed individuals and its exacerbation, with vaccination against COVID-19 being a relevant factor. The objective of the present study is to review the exacerbation of psoriasis, in patients already diagnosed and in new cases, after vaccination against COVID-19, trying to establish a causal relationship on which vaccines are most related to decompensation of the condition, having based on the cases reported so far in the literature. Furthermore, it is intended to elucidate the main hypotheses for this phenomenon. The search for articles was carried out in the Pubmed/Medline, SciELO, Cochrane Library and LILACS databases, using the following descriptors: Psoriasis; Exacerbation; COVID-19; Vaccination; Psoriasis; Exacerbation; COVID-19; Vaccine. The search was restricted to articles published from 2019 to 2022, and studies relevant to the topic were selected. After analyzing the selected articles, several cases of psoriasis flare were seen after vaccination, in particular the Pfizer and Astrazeneca vaccines. Therefore, physicians and other healthcare professionals should be aware of the possibility of manifestation and exacerbation of psoriasis after the COVID-19 vaccine, regardless of type and dose.