Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canarium solomonensee Leaves on H2O2 induced toxicity in SH-SY5Y cell line

Authors

  • Patil Hansraj Annarao
  • Shaktikumar Chandrashekhar Shivhare

Keywords:

Canarium solomonense, Neuroprotective Activity, Hydrogen Peroxide, Scopolamine-induced Amnesia, Memory Enhancement

Abstract

The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.

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Published

2024-01-11

How to Cite

Annarao, P. H., & Chandrashekhar Shivhare, S. (2024). Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canarium solomonensee Leaves on H2O2 induced toxicity in SH-SY5Y cell line. International Journal Of Chemistry, Mathematics And Physics(IJCMP), 8(01). https://journal-repository.com/index.php/ijcmp/article/view/6982