Effect of Poly Herbal Extract of Curcuma Amada Rhizome and Sida Spinosa Leaves on STZ-Induced Tissue Damage Marker Enzymes

Abstract

Diabetes mellitus (DM) remains a global health challenge with rising prevalence and associated complications. Among its various forms, Type 2 Diabetes (T2DM) poses a significant health concern. Chronic hyperglycemia in T2DM leads to oxidative stress, which, in turn, contributes to tissue damage and dysfunction. The present study investigates the potential therapeutic impact of a poly-herbal extract comprising Curcuma amada rhizome and Sida spinosa leaves on tissue damage marker enzymes in a Streptozotocin (STZ)-induced diabetic animal model. Curcuma amada, known as mango ginger, and Sida spinosa have long been acknowledged for their medicinal properties, often attributed to their rich content of bioactive compounds such as curcuminoids and flavonoids. These compounds possess antioxidant and anti-inflammatory properties, making them promising candidates for mitigating oxidative stress-induced tissue damage. In this research, an animal model for T2DM was induced using STZ, followed by the administration of the poly-herbal extract. Blood glucose levels were monitored throughout the study, and various tissue samples, including liver and kidney, were analyzed to assess the activity levels of tissue damage marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, and blood urea nitrogen (BUN). The findings of this study aim to shed light on the potential protective effects of the poly-herbal extract against STZ-induced tissue damage marker enzyme alterations. A thorough examination of these effects will offer insights into the therapeutic potential of herbal remedies in mitigating complications associated with T2DM. This research adds to the growing body of knowledge on complementary treatments for diabetes, bringing us one step closer to a more comprehensive understanding of the therapeutic potential of natural compounds in managing this widespread and challenging condition.