Synthesis & Pharmacological Activity of Cytotoxicity Assay of Coumarins SVCM1-SVCM7

Abstract

The therapeutic properties of natural and synthetic compounds against human illnesses have attracted a lot of interest. The pharmacological and biological effects of coumarins are widely exploited in medicine; they include anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antibacterial, and neuroprotective properties. Signaling pathways affecting many cellular functions may also be modulated by coumarin derivates. Whether or not a coumarin has pharmacological, biochemical, or therapeutic characteristics is dependent on the nature of the replacement surrounding the coumarin core structure. The capacity to kill, repel, or otherwise impact the development of Anopheles arabiensis mosquitoes was evaluated using seven synthetic halogenated coumarins (SVCM1-SVCM7). The compounds SVCM1-SVCM7 were evaluated for their bactericidal and fungicidal activities using the disc diffusion method.