Formulation and Evaluation of Floating in Situ Gel Based Gastro Retentive Drug Delivery of Cimetidine

Abstract

In this study, we formulate and evaluate an in-situ gel of cimetidine using sodium alginate and pectin. CaCO3 was employed as a cross-linking agent, while sodium alginate and pectin were used as polymers. The polymeric formulations used in in-situ gelation drug delivery systems are in sol form before injection in the body but form a gel in the body. Drug release is maintained and regulated thanks to the composition of the gel depending on elements such as temperature modulation, pH variations, the presence of ions, and ultra-violet irradiation. This research aimed to create a unique in-situ gel system for continuous medication administration by using biodegradable polymers found in nature. Polymers that undergo a sol-to-gel phase transition when certain physicochemical conditions are altered are used in this system. At a pH appropriate for life, an in-situ gel developed. Spectrophotometric analysis of the total quantity of drug release was performed during in vitro release investigations in gastric fluid models. The formulation with 1.2% sodium alginate and 1.5% pectin was able to regulate the release of the medicine for a longer period of time, as shown in a well-planned series of studies. Viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability, water absorption capacity, and sustained drug release were all characteristics of the in-situ gel that were consistent with expectations. The in-situ gels use a fickian diffusion mechanism to release the drugs.